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2月26日,日本大阪大学研究团队在《科学》(Science)在线发表研究论文Reconstitution of sex determination and the testicular niche using mouse pluripotent stem cells,报告他们利用小鼠多能干细胞对睾丸体细胞进行的重建工作。该重建过程重现了性别决定过程,产生了形成生精小管和相邻间质组织的细胞类型,重建的睾丸组织整合了多能干细胞来源的原始生殖细胞,并支持其分化为精原干细胞。这些精原干细胞在移植到睾丸后分化为具有功能的精子,且这些精子成功使卵子受精,并发育成健康且有生育能力的后代。
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